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KMID : 0043319970200040330
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.330 ~ p.337
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Reactions of3-Aminopyazole Derivatives with Cyanothioacetamide and Its Derivatives:Synthesis and Reactions of Several New Pyrazole and Pyrazole[3,2-b]Pyrimidine Derivatives
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Attaby Fawzy-A.
Eldin Sanaa-M.
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Abstract
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Thiocarboxamidocinnamonitrile derivatives 2 under bar a-f reacted with 3-aminopyrazole derivative 3 under bar a-c to give the pyrazole[3, 2-b]pyrimidine derivatives 6 under bar a-p. Compounds 6 under bar a-p were used as starting material for syntheses of several heterocylic coompounds. Dehydrogenation of 6 under bar gave pyrazole[3, 2-b]pyrimidines 10 under bar a-d while its reaction with diethyl oxalate gave 11 under bar. Reactions of 6 under bar with formic acid gave pyrazolopyrimidines 17 under bar a-j, and pyrazolopyrimidopyrimidines 18 under bar a-j.
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KEYWORD
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3-Aminopyrazole, Cyanothioacetamide, Pyrazole, Pyrazole[3, 2-b] pyrimidine
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